Is severe underarm sweating interfering with certainly daily activities? Are you afraid to raise your arms in normal situations because of underarm sweat stains? Then you may be a candidate for Botox/Dysport treatment. Botox is approved by the FDA to treat the symptoms of severe underarm sweating when medicines used on the skin (topical) do not work well enough Botox is injected in to the affected areas to help control this condition by temporarily blocking the chemical signals from the nerves that stimulate the sweat glands. When the sweat glands don’t receive chemical signals, the severe sweating stops.